At Pneuma Behavioral Health, we are proud to offer Spravato (esketamine) Therapy, a cutting-edge solution for adults living with treatment-resistant depression (TRD) or major depressive disorder with acute suicidal ideation. As one of the few FDA-approved medications specifically designed for TRD, Spravato provides a fast-acting, evidence-based alternative for individuals who have not found relief through traditional antidepressant medications.
Our REMS-certified facility and experienced providers ensure that this powerful therapy is delivered with the highest standards of safety, professionalism, and compassionate care.
Spravato is the brand name for esketamine, a chemically modified version of ketamine, designed to treat individuals struggling with major depressive disorder. Unlike most oral antidepressants that target serotonin, norepinephrine, or dopamine, Spravato acts on the glutamate system, the most abundant excitatory neurotransmitter in the brain.
Administered as a nasal spray under clinical supervision, Spravato enhances neuroplasticity, the brain’s ability to adapt and rewire, resulting in faster, more robust symptom improvement.
Spravato is FDA-approved for adults who meet one of the following criteria:
It is used in conjunction with an oral antidepressant and is typically not a standalone treatment. A thorough psychiatric evaluation at Pneuma Behavioral Health helps determine whether Spravato is the right fit for your specific needs.
Spravato works by blocking NMDA (N-methyl-D-aspartate) receptors in the brain, a mechanism that increases the activity of glutamate and leads to enhanced synaptic connectivity. This effect is believed to:
This unique mechanism allows for a faster onset of antidepressant effects compared to traditional oral medications that may take weeks to show results.
Initial Psychiatric Evaluation
Treatment begins with a full psychiatric assessment to evaluate the patient’s clinical history, prior medication use, and overall health profile.
Induction Phase (Weeks 1–4)
Maintenance Phase (Weeks 5 and beyond)
Spravato sessions are conducted in a calming, private setting at Pneuma Behavioral Health. The process includes:
Side effects are typically mild to moderate and may include dizziness, nausea, dissociation, or temporary increases in blood pressure. Our team is trained to manage these effects effectively and respectfully.
We require clients to arrange transportation home following each treatment, as driving is not permitted on the day of administration.
Integrates with existing treatments including medications and psychotherapy
Yes. Many commercial insurance providers offer coverage for Spravato, especially when prescribed for FDA-approved indications. Our administrative team assists with benefits verification, prior authorizations, and co-pay support programs, helping you access this treatment affordably.
At Pneuma, we view Spravato as one part of a broader healing journey. Our providers collaborate with a patient’s existing mental health team to integrate this therapy into a full treatment plan that may include talk therapy, psychiatric medications, wellness strategies, and lifestyle modifications.
We believe in education, empowerment, and engagement, ensuring you are informed and involved every step of the way.
If you or your loved one is living with depression that hasn’t responded to conventional medications, you are not alone and you have options. Spravato therapy offers a breakthrough alternative that is both safe and effective for eligible adults.
Contact Pneuma Behavioral Health today to schedule a consultation and discover whether Spravato could be the key to reclaiming your mental wellness.
No. While both Spravato and ketamine are derived from the same parent compound, Spravato is a patented nasal spray formulation of esketamine, which is a more potent isomer of ketamine. Spravato is FDA-approved for treatment-resistant depression and administered in a REMS-certified clinic under strict medical supervision.
Many clients report a noticeable improvement in depressive symptoms within the first few sessions, often within hours to days. However, response time varies depending on individual health history, severity of symptoms, and concurrent treatments.
Some of the most common side effects include dizziness, nausea, dissociation, fatigue, and elevated blood pressure. These effects are usually short-lived and are closely monitored during and after each session. Our team is trained to ensure your comfort and safety throughout.
No. Due to its temporary impact on cognition and motor coordination, clients are not permitted to drive on the day of treatment. You must arrange for transportation to and from the clinic for each Spravato session.
Yes, most commercial insurance plans cover Spravato when prescribed for FDA-approved indications. Our team will assist you with insurance verification, prior authorizations, and guide you through co-pay assistance programs to help make your treatment as accessible and affordable as possible.
